Piperazin-1-yl-pyrrolidin-1-yl-methanone → HCID 24810015, Verbindung

HRID 1446194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446194
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[N:16]1([C:22]([N:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:19]2[CH2:18][CH2:17][N:16]([C:22]([N:24]3[CH2:25][CH2:26][CH2:27][CH2:28]3)=[O:23])[CH2:21][CH2:20]2)=[O:15])=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 2760443Piperazin-1-yl-pyrrolidin-1-yl-methanoneHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Produkt 1

HCID 24810015HCID 24810015, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and piperazin-1-yl-pyrrolidin-1-yl-methanone (11.0 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.7 mg). Calcd for C20H24N4O3: 368.1848, found 368.1847.

Aufarbeitung

  1. custompurified by preparative HPLC method B

Quellen und Nachweise

ORD-Eintrag
ord-022dd04b6c094ad89df717e2604916b4
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666888B2

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