3-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1) → 4-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole

HRID 1446215Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446215
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[CH3:17][C:18]1[CH:29]=[CH:28][C:21]([CH2:22][CH:23]2[CH2:27][CH2:26][NH:25][CH2:24]2)=[CH:20][CH:19]=1>>[CH3:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][CH:23]2[CH2:27][CH2:26][N:25]([C:13]([C:9]3[CH:10]=[N:11][O:12][C:8]=3[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)=[O:15])[CH2:24]2)=[CH:28][CH:29]=1

Komponenten

3

Edukt 2

HCID 177497553-[(4-Methylphenyl)methyl]pyrrolidine--hydrogen chloride (1/1)HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Produkt 1

HCID 591702544-{[3-(4-Methylbenzyl)pyrrolidin-1-yl]carbonyl}-5-(4-methylphenyl)isoxazole

Versuchsvorschrift

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methylbenzyl)pyrrolidine hydrochloride (12.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (5.8 mg). Calcd for C23H24N2O2: 360.1838, found 360.1848.

Aufarbeitung

  1. custompurified by preparative HPLC method B

Quellen und Nachweise

ORD-Eintrag
ord-e8a0c8e302e24b4ca2d2f22db1d16392
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666888B2

Notizen zur Reaktion

Wird geladen…