1,2,3,4-Tetrahydro-2-naphthoic acid → 2-Methyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

HRID 1446383Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446383
O1C=CC[CH:2]1C(O)=O.[CH2:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH:10]1[C:19]([OH:21])=[O:20].CC(C)([O-])C.[K+].C[Si](C)(C)[N-][Si](C)(C)C.[K+]>O1CCCC1>[CH3:2][C:10]1([C:19]([OH:21])=[O:20])[CH2:11][CH2:12][C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:9]1

Komponenten

6

Edukt 4

HCID 1013701,2,3,4-Tetrahydro-2-naphthoic acidHCID 3251421Potassium bis(trimethylsilyl)amideHCID 202775472,3-Dihydrofuran-2-carboxylic acidHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 125628822-Methyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The title compound was prepared following the procedures described for Reference Example 5 substituting 2,3-dihydrofuran-2-carboxylic acid with 1,2,3,4-tetrahydro-2-naphthoic acid at Step A and potassium tert-butoxide in tetrahydrofuran with potassium hexamethyldisilazide (0.5 M in toluene) at Step B. 1H NMR (500 MHz, CD3OD): δ 7.12-7.0 (m, 4H), 3.71 (d, 1H), 3.22 (d, 1H), 2.84 (t, 1H), 2.65 (d, 1H), 2.17 (m, 1H), 1.77 (m, 1H), 1.28 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-4da4126bfeb5450d9e3874d076c46ab9
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07667053B2

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