2-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide → 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide

HRID 1446826Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446826
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH:17](SC)[C:18]([NH2:20])=[O:19]>[Ni].C(O)C.CN(C)C=O>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5]([Cl:16])=[CH:4][C:3]=1[CH2:17][C:18]([NH2:20])=[O:19]

Komponenten

5

Edukt 1

HCID 670799562-Amino-3-benzoyl-5-chloro-α-(methylthio)benzeneacetamide

Produkt 1

HCID 178767402-AMino-3-benzoyl-5-chlorobenzeneacetaMide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 21.34 g (0.0639 mole) of 2-amino-3-benzoyl-5-chloro-α-(methylthio)-phenylacetamide and excess Raney nickel in a mixture of 900 ml of absolute ethanol and 200 ml of dimethylformamide was stirred at room temperature for 45 min. The mixture was filtered through celite to remove the Raney nickel. The solvent was removed in vacuo to give a yellow solid which when recrystallized melted at 213.5°-215.0° C.(d).

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. customto remove the Raney nickel
  3. customThe solvent was removed in vacuo
  4. customto give a yellow solid which when
  5. customrecrystallized melted at 213.5°-215.0° C.(d)

Quellen und Nachweise

ORD-Eintrag
ord-3d4b8b6afa974027b6a4a17c4d914055
Quelldatensatz
uspto-grants-1982_02
Patentnummer
US04313949

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