2-Chloroaniline → 1-(2-Chlorophenyl)pyrrolidin-2-one

Reaktionsgleichung

[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]1(=O)[O:13][CH2:12][CH2:11][CH2:10]1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]1[CH2:9][CH2:10][CH2:11][C:12]1=[O:13]

Komponenten

Edukt 2

HCID 72402-Chloroaniline

HCID 7302Gamma-Butyrolactone

Produkt 1

HCID 41405531-(2-Chlorophenyl)pyrrolidin-2-oneAusbeute 25,4 %

Versuchsvorschrift

Following example 19, 12.57 g (0.1 M) of 2-chloroaniline and 9.5 g (0.11 M) of γ-butyrolactone were heated for 48 hours. The excess starging materials were removed at 50°-80°/0.3 mm. Distillation of the residue gave 4.9 g (25%) of product (45% based on recovered 2-chloroaniline); b.p. 150°-155°/0.3-0.4 mm.

Aufarbeitung

temperaturewere heated for 48 hours
customThe excess starging materials were removed at 50°-80°/0.3 mm
distillationDistillation of the residue

Quellen und Nachweise

ORD-Eintrag: ord-9ea4afa9312a4c4cbe16ba4449aa05ab
Quelldatensatz: uspto-grants-1982_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04316893

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