Carprofen → HCID 20382818, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]=[C:8]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])[CH:7]=[CH:6][C:5]2=1.ClC1C=C2C(=CC=1)NC1C=C(C(O)(C)C(O)=O)C=CC2=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]=[C:8]([C:15](=[CH2:19])[C:16]([OH:18])=[O:17])[CH:7]=[CH:6][C:5]2=1Komponenten
3
Versuchsvorschrift
In yet another aspect, the invention relates to the process of preparing 6-chloro-α-methylcarbazole-2-acetic acid by a process which comprises the steps of (a) treating 6-chloro-α-hydroxy-α-methylcarbazole-2-acetic acid with a dehydrating agent to yield 6-chloro-α-methylene-2-carbazole acetic acid; (b) hydrogenating the reaction product of step (a) to obtain the desired 6-chloro-α-methylcarbazole-2-acetic acid. Alternatively, the 6-chloro-α-hydroxy-α-methylcarbazole-2-acetic acid can be treated with stannous chloride in the presence of an alkanoic and mineral acid to yield the desired 6-chloro-α-methylcarbazole-2-acetic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-1bc1d1f9d62a448f9eeeb0c72d2b3d8a
- Quelldatensatz
- uspto-grants-1979_12