N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide → 2-Methyl-N-(5-methylthiophen-2-yl)propanamide
Reaktionsgleichung
C([C:5]1[CH:9]=[C:8]([CH3:10])[S:7][C:6]=1[NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])(OC)=O.O.O.[I-].[Li+]>>[CH3:10][C:8]1[S:7][C:6]([NH:11][C:12](=[O:16])[CH:13]([CH3:14])[CH3:15])=[CH:5][CH:9]=1Komponenten
3
Versuchsvorschrift
The ester from Example 48 was treated with lithium iodide dihydrate as in Example 42 to give the expected decarboxylated product, N-(5-methyl-2-thienyl)-2-methylpropanamide, m.p. 96°-97° C. in 54% yield.
Quellen und Nachweise
- ORD-Eintrag
- ord-2810ea2fd5254c46896b46f074f3346a
- Quelldatensatz
- uspto-grants-1980_02
- Patentnummer
- US04187232
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