Hydrochloric Acid → HCID 4090534, Verbindung

HRID 1448955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1448955
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(=[O:4])=[O:3].Cl.[H][H]>C(O)C.[Pt]=O>[CH3:1][S:2]([NH:5][CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:3])=[O:4]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 2797875HCID 2797875, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 4090534HCID 4090534, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

4-(2-Methanesulphonamidoethyl)pyridine (8.4 g.) in ethanol (85 ml.) was acidified to pH 2 with 2 N HCl and hydrogenated at room temperature and a pressure of 50 p.s.i. over a platinum oxide catalyst until hydrogen uptake ceased. The catalyst was then removed by filtration and the filtrate was taken to dryness in vacuo to give a white solid which was dissolved in the minimum volume of hot ethanol, filtered quickly, and left at room temperature overnight. The resultant white crystals were collected by filtration and dried to yield 4-(2-methanesulphonamidoethyl)piperidine:hydrochloride (8.3 g.), m.p. 165°-167° C.

Aufarbeitung

  1. customThe catalyst was then removed by filtration
  2. customto give a white solid which
  3. filtrationfiltered quickly
  4. filtrationThe resultant white crystals were collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4aac70de735d44b492ea379ce43e2412
Quelldatensatz
uspto-grants-1980_02
Patentnummer
US04188391

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