Methyl phenethylcarbamate → 3,4-dihydroisoquinolin-1(2H)-one

Beteiligte Stoffe

Reaktionsschritte

To a solution of polyphosphoric acid (200 mL) at 140° C. N-methoxycarbonyl-phenethylamine (28 g, 0.16 mol) was added portionwise over a 5 hour period. The reaction solution was poured into cold water (400 mL) and extracted with methylene chloride (5×200 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the title compound (17.96 g, 86% yield).

Herkunft & Nachweise