Benzene → 5-(1-Hydroxypropyl)-3-phenylisoxazole

HRID 1450637

Reaktionsgleichung

Reaktionsgleichung von HRID 1450637
C1(C(NCl)=[O:8])C=CC=CC=1.[CH:11]#[C:12][CH:13]([OH:16])[CH2:14][CH3:15].C([N:19]([CH2:22][CH3:23])CC)C.[CH:24]1C=[CH:28][CH:27]=[CH:26][CH:25]=1>>[OH:16][CH:13]([C:14]1[O:8][N:19]=[C:22]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:15]=1)[CH2:12][CH3:11]

Komponenten

5

Edukt 4

HCID 241BenzeneHCID 8471TriethylamineHCID 929811-Pentyn-3-olHCID 12256294Benzamide, N-chloro-

Produkt 1

HCID 151807655-(1-Hydroxypropyl)-3-phenylisoxazole

Versuchsvorschrift

Dissolved in 200 ml of benzene were 18.5 g (0.12 mol) of benzenehydroxamic acid chloride synthesized in accordance with a known process [J. Org. Chem., 45, 3916 (1980)] and 10.0 g (0.12 mole) of 1-pentyne-3-ol, followed by the dropwise addition of 18 g (0.18 mol) of triethylamine under ice cooling. After they were reacted under reflux for 10 hours, the reaction mixture was washed with water and the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (eluent: chloroform), whereby 5-(1-hydroxypropyl)-3-phenylisoxazole was obtained as colorless crystals.

Aufarbeitung

  1. customAfter they were reacted
  2. temperatureunder reflux for 10 hours
  3. washthe reaction mixture was washed with water
  4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure
  6. customThe resulting residue was purified by chromatography on a silica gel column (eluent: chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-72b138b7494d4b02a1e7c20647ea9ca9
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05602160

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