Boc-orn(boc)-OH → N,N'-bis-BOC-Ornithine tert-Butyl Ester
Reaktionsgleichung
[C:1]([NH:8][C@H:9]([C:21]([OH:23])=[O:22])[CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>C(Cl)(Cl)Cl>[C:4]([O:22][C:21](=[O:23])[C@H:9]([CH2:10][CH2:11][CH2:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[NH:8][C:1]([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2])([CH3:7])([CH3:6])[CH3:5]Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
N,N'-bis-BOC-Ornithine tert-Butyl Ester (22) was synthesized from N,N'-bis-BOC-ornithine (12) according to the general procedure : yield, 86%; mp 80°-82° C.; [α]25D+11.3° (c 1.3, CHCl3); 1H NMR δ 5.07 (br d, 1H, J=7.8), 4.63 (m, 1H), 4.16 (t, 1H, J=6.9), 3.14 (t, 2H, J=6.0), 1.82-150 (m, 4H), 1 .45 (s, 9H), 1.43 (s, 18H). Anal. Calcd for C19H36N2O6 : C, 58.7; H, 9.3,; N, 7.2. Found: C, 58.7; H, 9.7; N, 7.2.
Aufarbeitung
- customyield