Sodium Hydroxide → 3-Aminomethylbenzoic acid hydrate
Reaktionsgleichung
Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>>[OH2:8].[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8]Komponenten
3
Versuchsvorschrift
A mixture of methyl 3-aminomethylbenzoate hydrochloride (2.014 g, 0.0098 mol) in 1N sodium hydroxide (25 mL, 0.025 mol) was stirred at room temperature for 4 h. The mixture was neutralized with Dowex-H+ resin. The mixture was filtered and acetone (400 mL) was added to the filtrate. The white precipitate was collected by filtration and recrystallized from water-acetone to give 0.80 g of the title compound as a white powder, mp 278°-280° C.
Aufarbeitung
- filtrationThe mixture was filtered
- additionacetone (400 mL) was added to the filtrate
- filtrationThe white precipitate was collected by filtration
- customrecrystallized from water-acetone
Quellen und Nachweise
- ORD-Eintrag
- ord-94ff83784eb24d4b963ddcaf7afab86b
- Quelldatensatz
- uspto-grants-1997_02
- Patentnummer
- US05602277
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