Triethylamine → 4,5-dichloro-6-[3-(phenylthio)propyloxy]-3(2H)-pyridazinone

HRID 1451229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1451229
Br[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl:12][C:13]1[C:14](=[O:21])[NH:15][N:16]=[C:17]([OH:20])[C:18]=1[Cl:19].C(N(CC)CC)C>CN(C)C=O>[Cl:12][C:13]1[C:14](=[O:21])[NH:15][N:16]=[C:17]([O:20][CH2:2][CH2:3][CH2:4][S:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:18]=1[Cl:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 70618473-Bromopropyl phenyl sulfideHCID 178518839HCID 178518839, Verbindung

Produkt 1

HCID 199743804,5-dichloro-6-[3-(phenylthio)propyloxy]-3(2H)-pyridazinoneAusbeute 66,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

After 1.57 g of 1-bromo-3-phenylthiopropane, 2 g of 4,5-dichloro-6-hydroxy-3(2H)-pyridazinone and 1.3 g of triethylamine were dissolved in dimethylformamide, the mixture was stirred at room temperature for 24 hours. The reaction mixture was poured onto water. The formed crystals were taken by filtration and thoroughly washed with water. The crystals were recrystallized from ethanol to give 1.5 g of the objective compound. Yield, 52%, Melting point, 187°-188° C.

Aufarbeitung

  1. additionThe reaction mixture was poured onto water
  2. filtrationThe formed crystals were taken by filtration
  3. washthoroughly washed with water
  4. customThe crystals were recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ce26d6e61583406e996a61aab7cd2a1a
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05604226

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