Hydrochloric Acid → 10-(2-Carboxyethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione

HRID 1451305

Reaktionsgleichung

Reaktionsgleichung von HRID 1451305
C([O:3][C:4]([CH2:6][CH2:7][NH:8][C:9]1[C:18]2[CH:17]=[CH:16][C:15]([Cl:19])=[CH:14][C:13]=2[N:12]=[C:11]2[C:20](=[O:25])[NH:21][NH:22][C:23](=[O:24])[C:10]=12)=[O:5])C.Cl>>[C:4]([CH2:6][CH2:7][NH:8][C:9]1[C:18]2[CH:17]=[CH:16][C:15]([Cl:19])=[CH:14][C:13]=2[N:12]=[C:11]2[C:20](=[O:25])[NH:21][NH:22][C:23](=[O:24])[C:10]=12)([OH:5])=[O:3]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 1892994110-(2-Ethoxycarbonylethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione

Produkt 1

HCID 1892987710-(2-Carboxyethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dioneAusbeute 97 %

Versuchsvorschrift

A mixture of 10-(2-ethoxycarbonylethylamino)-7-chloro-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione (0.08 g, 0.22 mM) and 1N hydrochloric acid was refluxed for 1 hr and then cooled to room temperature and filtered. The collected orange solid was washed with water and air dried to provide (0.07 g, 97%) the title compound as an orange powder, mp 356°-359° C.; MS(CI): 335 (M+H). Analysis for C14H11ClN4O4 ·0.3 H2O: Calculated: C, 49.4; H, 3.44; N, 16.47 Found: C, 49.3; H, 3.23; N, 16.25

Aufarbeitung

  1. temperaturewas refluxed for 1 hr
  2. filtrationfiltered
  3. washThe collected orange solid was washed with water and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ec712ca8c37f495f81e1ff1b03a8d371
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05604227

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