HCID 11088367, Verbindung → HCID 19974099, Verbindung

HRID 1451359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1451359
[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].C[O:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1>Br>[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[OH:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1

Komponenten

3

Edukt 1

HCID 11088367HCID 11088367, Verbindung

Produkt 1

HCID 19974099HCID 19974099, VerbindungAusbeute 15 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 260Hydrogen BromideLösungsmittel

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

A mixture of 9-methoxy-thiazolo[3,2-b]isoquinolinium perchlorate (7 g, 22.19 mmol) in 100 ml of 48% HBr was heated for 18 hours at 115° C. The mixture was concentrated in vacuo, the residue was dissolved in warm water and filtered. The filtrate was treated with sodium perchlorate, the resulting solid was filtered, and washed with water to afford 1.0 g (15%) of 9-hydroxy-thiazolo[3,2-b]isoquinolinium perchlorate (Formula II: A=thiazolo; R1 =H; R6 =9-OH; X- =ClO4-).

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionthe residue was dissolved in warm water
  3. filtrationfiltered
  4. additionThe filtrate was treated with sodium perchlorate
  5. filtrationthe resulting solid was filtered
  6. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-ef88c70a30c64e83b2f689109e61ec5f
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05604224

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