Hydrogen Bromide → 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2.8 g (0.02 mol) of 2,5-Dimethyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 35% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 100° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 2 hours the solvent is removed, and the residue is triturated with 50 ml of ether and filtered off with suction.

Herkunft & Nachweise