Sodium Hydroxide → 4-(3-Bromopropoxy)aniline

HRID 1451643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1451643
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12]C(=O)C)=[CH:8][CH:7]=1.[OH-].[Na+]>Cl>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10849771N-[4-(3-bromopropoxy)phenyl]acetamide

Produkt 1

HCID 199745634-(3-Bromopropoxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A mixture of the product of part (i) above (13 g) and 5N hydrochloric acid (200 ml) was heated under reflux for 2 h. After cooling, the mixture was basified with sodium hydroxide solution and extracted with dichloromethane. The organic phase was evaporated to give the title compound (7 g) as an oil. IR includes a peak at 3360-3450 cm-1 (NH).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureAfter cooling
  4. extractionextracted with dichloromethane
  5. customThe organic phase was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-844f3f95de144ec39e3629178d3a957b
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05604237

Notizen zur Reaktion

Wird geladen…