Thionyl Chloride → HCID 19973449, Verbindung

HRID 1452043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1452043
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, Verbindung

Produkt 1

HCID 19973449HCID 19973449, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

6.80 g of the 2-methylimidazo-[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

Aufarbeitung

  1. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-d68fb8fe4ccd4e2a87e4aac04f1400b6
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05606061

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