Potassium Carbonate → 2-Bromo-3-(but-2-ynyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

HRID 1453542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1453542
[Br:1][C:2]1[N:3]([CH2:12][C:13]#[C:14][CH3:15])[C:4]2[C:9](=[O:10])[NH:8][N:7]=[CH:6][C:5]=2[N:11]=1.Cl[CH2:17][C:18]1[N:27]=[C:26]([CH3:28])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[N:3]([CH2:12][C:13]#[C:14][CH3:15])[C:4]2[C:9](=[O:10])[N:8]([CH2:17][C:18]3[N:27]=[C:26]([CH3:28])[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]=3)[N:7]=[CH:6][C:5]=2[N:11]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 2415182-(Chloromethyl)-4-methylquinazolineHCID 219476582-Bromo-3-(but-2-ynyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Produkt 1

HCID 160377782-Bromo-3-(but-2-ynyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 365 mg 2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 265 mg 2-chloromethyl-4-methyl-quinazoline and 210 mg potassium carbonate in 6 ml acetonitrile is stirred for 17 h at ambient temperature. Then the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate and the filtrate is evaporated down. The residue is triturated in diisopropylether, separated from the ether and dried.

Aufarbeitung

  1. filtrationThen the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate
  2. customthe filtrate is evaporated down
  3. customThe residue is triturated in diisopropylether
  4. customseparated from the ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5e1303b1d90540ba8b0d67eb9bde0c84
Quelldatensatz
uspto-grants-2009_01
Patentnummer
US07476671B2

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