Trifluoroacetic acid → 1-(3-Amino-2-hydroxy-4-phenyl-butyl)-piperidine-3-carboxylic acid [4-phenyl-1-(3-phenyl-propyl)-butyl]-amide

(1-Benzyl-2-hydroxy-3-{3-[4-phenyl-1-(3-phenyl-propyl)-butylcarbamoyl]-piperidine-1-yl}-propyl)-carbamic acid tert-butyl ester (19) (194.4 mg; 0.3 mmol) is dissolved in methylene chloride (5 mL) at ambient temperature. Trifluoroacetic acid (5 mL) is added in a slow stream, and the solution is stirred for 90 minutes at ambient temperature. The solution is concentrated in vacuo at 40° C. The residue is slurried in a mixture of methylene chloride (10 mL) and water (100 mL), then potassium carbonate is added until the slurry is alkaline. The slurry is diluted with water (50 mL) then extracted with methylene chloride (3×50 mL). The organic extracts are dried over MgSO4, filtered, and concentrated in vacuo affording the desired product (150 mg) as an oil.

1. concentrationThe solution is concentrated in vacuo at 40° C
2. additionThe residue is slurried in a mixture of methylene chloride (10 mL) and water (100 mL)
3. additionpotassium carbonate is added until the slurry
4. additionThe slurry is diluted with water (50 mL)
5. extractionthen extracted with methylene chloride (3×50 mL)
6. dry with materialThe organic extracts are dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo

ORD-Eintrag

ord-59f586be8e6447dca2a5f09058495006

Quelldatensatz

uspto-grants-2009_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07476680B2