HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| Edukt | 4-(2-Butynyloxy)-5-fluoro-6-chloropyrimidine | HCID 22599717 | — |
| Produkt | 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine | HCID 59341148 | 101,4% |
Reaktionsschritte
0.2 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 1-(6-(2-butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (53)).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732448B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-83ad6d2e8682477ebd923d867eee68c3 |
| Quellennotiz | uspto-grants-2010_06 |