Sulfuric Acid → Butyl 1,6-dihydro-6-oxo-3-pyridazinecarboxylate

HRID 1455945

Reaktionsgleichung

Reaktionsgleichung von HRID 1455945
[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]([OH:10])=[O:9])[CH:4]=[CH:3]1.C(O[CH2:15][CH2:16][CH2:17][CH3:18])(=O)C.OS(O)(=O)=O>C(O)CCC>[O:1]=[C:2]1[NH:7][N:6]=[C:5]([C:8]([O:10][CH2:15][CH2:16][CH2:17][CH3:18])=[O:9])[CH:4]=[CH:3]1

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 31272Butyl AcetateHCID 3059706-Hydroxypyridazine-3-carboxylic Acid

Produkt 1

HCID 12346430Butyl 1,6-dihydro-6-oxo-3-pyridazinecarboxylateAusbeute 79,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 6-oxo-1,6-dihydropyridazine-3-carboxylic acid (117.24 g) [Ref: British Patent 856, 409], n-butyl acetate (293 ml), n-butanol (410 ml) and conc. H2SO4 (5.9 ml) was heated at reflux for 1 hour. The solvent was evaporated and the residue washed with n-butyl acetate to give n-butyl 6-oxo-1,6-dihydropyridazine-3-carboxylate (130.6 g, 79.6% yield), mpt 79°-8° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. customThe solvent was evaporated
  4. washthe residue washed with n-butyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b7c6fe4f533846a2811c09e57cbf908f
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05843942

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