Triethylamine → HCID 22104000, Verbindung

HRID 1457227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457227
C1(N=C=NC2CCCCC2)CCCCC1.[C:16]([NH:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl.[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH2:39])[CH3:35].C(N(CC)CC)C.ON1C2C=CC=CC=2N=N1>O1CCCC1>[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH:39][C:30](=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][NH:24][C:16](=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH3:35]

Komponenten

7

Edukt 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 703886-Benzamidohexanoic acidHCID 757711-HydroxybenzotriazoleHCID 2723640Glycine ethyl ester, hydrochloride

Produkt 1

HCID 22104000HCID 22104000, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of dicyclohexylcarbodiimide (112 mmoles) in anhydrous tetrahydrofuran (44 ml) was gradually added to a suspension of N-benzoyl-6-aminohexanoic acid (93.5 mmoles), prepared as described in example 1, glycine ethyl ester hydrochloride (112 mmoles), triethylamine (112 mmoles) and anhydrous 1-hydroxybenzotriazole (112 mmoles) in tetrahydrofuran (330 ml), kept under stirring at 0° C. The reaction mixture was brought at room temperature and kept under stirring for 16 hours.

Aufarbeitung

  1. customprepared
  2. customwas brought at room temperature
  3. stirringunder stirring for 16 hours

Quellen und Nachweise

ORD-Eintrag
ord-72d1a84a6c4e45029ce97a96436ac908
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05847092

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