Hydrochloric Acid → Methyl 12-aminododecanoate--hydrogen chloride (1/1)

HRID 1457531

Reaktionsgleichung

Reaktionsgleichung von HRID 1457531
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[ClH:16].[CH3:17]OC(OC)(C)C>>[ClH:16].[CH3:17][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 6966112-Aminododecanoic Acid

Produkt 1

HCID 19372000Methyl 12-aminododecanoate--hydrogen chloride (1/1)Ausbeute 90,5 %

Versuchsvorschrift

To the suspension of 12-aminododecanoic acid (2.15 g; 10 mmol) in 2,2-dimethoxypropane (100 ml) was added 36% aqueous HCl (10 ml) and the mixture was treated in an ultrasonic bath until all solid material was dissolved. The mixture was then left to stand overnight, concentrated to dryness, dissolved in 40 ml of methanol and precipitated with approximately 500 ml of dry ether to give 2.4 g of 1 (90.5% yield).

Aufarbeitung

  1. additionthe mixture was treated in an ultrasonic bath until all solid material
  2. dissolutionwas dissolved
  3. waitThe mixture was then left
  4. concentrationconcentrated to dryness
  5. dissolutiondissolved in 40 ml of methanol
  6. customprecipitated with approximately 500 ml of dry ether

Quellen und Nachweise

ORD-Eintrag
ord-d2eabb1642dc4adaa8ccee71a480e632
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849691

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