2-chloro-N-ethylbenzamide → n-Ethyl-2-chloro-6-(ethenyldimethylsilyl)benzamide

HRID 1458067

Reaktionsgleichung

Reaktionsgleichung von HRID 1458067
[CH2:1]([NH:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH:13]([Si:15](Cl)([CH3:17])[CH3:16])=[CH2:14]>>[CH2:1]([NH:3][C:4](=[O:12])[C:5]1[C:10]([Si:15]([CH:13]=[CH2:14])([CH3:17])[CH3:16])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2]

Komponenten

3

Edukt 2

HCID 3479622-chloro-N-ethylbenzamideHCID 519368Chloro(dimethyl)vinylsilane

Produkt 1

HCID 18630374n-Ethyl-2-chloro-6-(ethenyldimethylsilyl)benzamide

Versuchsvorschrift

The title compound was prepared from the compound of Example f and 1.5 eq vinyldimethylsilyl chloride according to General Method C. Purification by HPLC with 1:4 ethyl acetate/hexanes gave 630 mg of the desired product as a white solid, a 9% yield. m.p. 86°-89° C.

Aufarbeitung

  1. customPurification by HPLC with 1:4 ethyl acetate/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-f41fb434b0364ef5b3c5fa6862771126
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849723

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