Methyl Isocyanate → N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide

HRID 1458560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1458560
[CH3:1][N:2]=[C:3]=[O:4].[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH2:28])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2>ClCCl>[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH:28][C:3]([NH:2][CH3:1])=[O:4])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2

Komponenten

4

Edukt 2

HCID 12228Methyl IsocyanateHCID 54554464HCID 54554464, Verbindung

Produkt 1

HCID 22097020N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamideAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Methylisocyanate (8.2 μl, 8.0 mg, 0.14 mmol) was added to a solution of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-aminoethyl)-methanesulphonamide (from Preparation 27, 50 mg, 0.127 mmol) in dichloromethane (2 ml) at room temperature under nitrogen. After 30 minutes the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and concentrated under reduced pressure to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide as a pale yellow foam (52 mg, 91%).

Aufarbeitung

  1. concentrationAfter 30 minutes the mixture was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-790b989a9e4544fb98a0035504d2b89e
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05852016

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