Hydrochloric Acid → HCID 54321377, Verbindung

HRID 1458571Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1458571
[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54103043HCID 54103043, Verbindung

Produkt 1

HCID 54321377HCID 54321377, VerbindungAusbeute 84 %

Versuchsvorschrift

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxyquinoxaline (from step (a), 12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH3) and the solid which precipitated was filtered off, washed with water and ether, and dried in vacuo at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, m.p. 225°-227° C.

Aufarbeitung

  1. customthe solid which precipitated
  2. filtrationwas filtered off
  3. washwashed with water and ether
  4. customdried in vacuo at 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-8d770f62e6524feb864f26d52013763e
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05852016

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