HCID 22097613, Verbindung → Imidazole-1-butyric acid

HRID 1458950Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1458950
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1>[C].[Pd].C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1

Komponenten

4

Edukt 1

HCID 22097613HCID 22097613, Verbindung

Produkt 1

HCID 3055390Imidazole-1-butyric acidAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of benzyl 4-(1-imidazolyl)butyrate (7.4 g), palladium-carbon (5%)(1.0 g) and ethanol (400 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the crystals were recrystallized from ethanol to give 4-(1-imidazolyl)butyric acid (3.4 g, 75%). Colorless prisms. mp. 125°-126° C.

Aufarbeitung

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe crystals were recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-6baa2d2489df46e79ff455de90459d12
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05852039

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