Thionyl Chloride → 1-(Chloromethyl)-2,3-dimethoxybenzene

HRID 1460182

Reaktionsgleichung

Reaktionsgleichung von HRID 1460182
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:15])=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Cl:15]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 797382,3-Dimethoxybenzyl alcohol

Produkt 1

HCID 27583941-(Chloromethyl)-2,3-dimethoxybenzeneAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

In 30 ml of methylene chloride was dissolved 3.36 g (20 mmol.) of 2,3-dimethoxybenzyl alcohol. Under chilling with ice, to the solution was dropwise added a solution of 1.6 ml (22 mmol.) of thionyl chloride in 5 ml of methylene chloride for 10 min. The mixture was stirred at the same temperature and then placed under reduced pressure to distill off the solvent, to give 3.71 g of 2,3-dimethoxybenzyl chloride as a brown oil, yield 99.5%.

Aufarbeitung

  1. temperatureUnder chilling with ice, to the solution
  2. distillationto distill off the solvent

Quellen und Nachweise

ORD-Eintrag
ord-fb0d730526ee4ac28be8685929e0b77f
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05070089

Verknüpfte Notizen

Wird geladen…