HCID 19100959, Verbindung → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1460774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460774
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

Komponenten

3

Edukt 1

HCID 19100959HCID 19100959, Verbindung

Produkt 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl -2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times with 50 ml of chloroform each time
  3. dry with materialdried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-d7d525b1bf1644beb95e52e2b90c38a9
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071999

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