HCID 19100973, Verbindung → HCID 19100943, Verbindung

HRID 1460798Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460798
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

Komponenten

3

Edukt 1

HCID 19100973HCID 19100973, Verbindung

Produkt 1

HCID 19100943HCID 19100943, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl -2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight in 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-8c248f55d9ea445285a4869bd925270d
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071999

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