1-Propanol → 4-n-Propoxy-3-pyrrolin-2-one

HRID 1460833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460833
[CH3:1][O:2][C:3]1[CH2:7][NH:6][C:5](=[O:8])[CH:4]=1.CS(O)(=O)=O.[CH2:14](O)[CH2:15]C>>[CH2:1]([O:2][C:3]1[CH2:7][NH:6][C:5](=[O:8])[CH:4]=1)[CH2:14][CH3:15]

Komponenten

4

Edukt 3

HCID 10311-PropanolHCID 6395Methanesulfonic AcidHCID 5747694-methoxy-2,5-dihydro-1H-pyrrol-2-one

Produkt 1

HCID 199826134-n-Propoxy-3-pyrrolin-2-one

Versuchsvorschrift

A mixture of 4-methoxy-3-pyrrolin-2-one (3 g), 1-propanol (3.5 ml) and methanesulfonic acid (0.2 g) was refluxed for 2 hours in the presence of 3A molecular sieves. Solvent was removed from the mixture, and the residue chromatographed on silica gel, eluting with 2% methanol in methylene chloride, to give 4-n-propoxy-3-pyrrolin-2-one.

Aufarbeitung

  1. customSolvent was removed from the mixture
  2. customthe residue chromatographed on silica gel
  3. washeluting with 2% methanol in methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-a0f4d5dcab2c40ed8a7ffd7f4f79a489
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05072006

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