4-Fluoro-4'-hydroxybiphenyl → Rac-4-[2-(4'-fluoro-biphenyl-4-yloxy)-propionylamino]-thiophene-3-carboxylic acid

HRID 14613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 14613
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:15])[CH:12](Cl)[CH3:13])=[CH:8][S:7][CH:6]=1)=[O:4].[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH:12]([CH3:13])[C:11]([NH:10][C:9]3[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][CH:8]=3)=[O:15])=[CH:25][CH:24]=2)=[CH:21][CH:22]=1

Komponenten

3

Edukt 2

HCID 3454204-Fluoro-4'-hydroxybiphenylHCID 68688356Rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester

Produkt 1

HCID 16068684Rac-4-[2-(4'-fluoro-biphenyl-4-yloxy)-propionylamino]-thiophene-3-carboxylic acid

Versuchsvorschrift

In analogy to Example 2, the title compound was prepared using rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester and 4′-fluoro-biphenyl-4-ol. MS (m/e): 384.1 (M−H).

Quellen und Nachweise

ORD-Eintrag
ord-7d3e5a1a3f0b4b65bf3bb044b40ce4ed
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732452B2

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