Hydrochloric Acid → 2-(3,5-Dichlorophenyl)propan-2-amine

HRID 1461651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1461651
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH:8]C=O)([CH3:7])[CH3:6].Cl.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH2:8])([CH3:6])[CH3:7]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15754135N-(3,5-dichloroalpha,alpha-dimethylbenzyl)formamide

Produkt 1

HCID 111950522-(3,5-Dichlorophenyl)propan-2-amineAusbeute 98 %

Versuchsvorschrift

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloroα,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minutes. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

Aufarbeitung

  1. temperaturewas refluxed for 30 minutes
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. washThe ether solution was washed with water
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e47868ddba874da7bb8fc5056ec5a666
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05076834

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