Dimethylamine → 1-Butanone, 2-(dimethylamino)-1-(4-(dimethylamino)phenyl)-2-(phenylmethyl)-

HRID 1461808

Reaktionsgleichung

Reaktionsgleichung von HRID 1461808
F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:22])[C:9]([N:19]([CH3:21])[CH3:20])([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:10][CH3:11])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:29][NH:30][CH3:31]>CN(C)C=O>[CH3:29][N:30]([CH3:31])[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:22])[C:9]([N:19]([CH3:21])[CH3:20])([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:10][CH3:11])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 193605992-Benzyl-2-(dimethylamino)-1-(4-fluorophenyl)butan-1-one

Produkt 1

HCID 1641061-Butanone, 2-(dimethylamino)-1-(4-(dimethylamino)phenyl)-2-(phenylmethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A stirred autoclave is filled with 50 g (0.167 mol) of 1-(4-fluorophenyl)-2-dimethylamino-2-benzylbutan-1-one (crude product from B), 300 ml of dimethylformamide and 23.1 g (0.167 mol) of potassium carbonate. 22.6 g (0.5 mol) of dimethylamine are then added under pressure (3-4 bar). The mixture is heated to 100° and stirred at this temperature for 24 hours.

Aufarbeitung

  1. temperatureThe mixture is heated to 100°

Quellen und Nachweise

ORD-Eintrag
ord-8e07e5cda52743a79a7241d5b9115f72
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05077402

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