Chlorodifluoroacetyl chloride → Rac-4-[2,2-difluoro-2-(4'-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[C:9]([NH2:10])=[CH:8][S:7][CH:6]=1)=[O:4].Cl[C:12]([F:17])([F:16])[C:13](Cl)=[O:14].[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1>>[F:16][C:12]([F:17])([O:31][C:28]1[CH:27]=[CH:26][C:25]([C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=2)=[CH:30][CH:29]=1)[C:13]([NH:10][C:9]1[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][CH:8]=1)=[O:14]Komponenten
4
Versuchsvorschrift
In analogy to Example 58, the title compound was prepared using 4-amino-thiophene-3-carboxylic acid methyl ester, chlorodifluoroacetyl chloride and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 406.1 (M−H).