Potassium Carbonate → 3-(Phenylamino)benzoic acid

HRID 1462029Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1462029
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([O:10]C)=[O:9])(=O)[CH3:2].I[C:16]1[CH:21]=CC=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>[N+](C)([O-])=O.[Cu]>[NH:4]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([OH:10])=[O:9])[C:1]1[CH:18]=[CH:17][CH:16]=[CH:21][CH:2]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 11575IodobenzeneHCID 592170Methyl 3-acetamidobenzoate

Produkt 1

HCID 128503413-(Phenylamino)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23978CopperKatalysatorHCID 6375NitromethaneLösungsmittel

Versuchsvorschrift

In accordance with the method described in Zhur. Obshchei Khim 30, 2693 (1960), methyl 3-acetylaminobenzoate was reacted with iodo benzene in nitromethane in the presence of potassium carbonate and active copper powder to yield 3-anilinobenzoic acid and the intended product was obtained by the following steps. ##STR254##

Quellen und Nachweise

ORD-Eintrag
ord-89069c65bd7b4545af2b742f404f2ec5
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04457940

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