5-(2-Methyl-2-nitropropoxy)salicylamide → 5-(2-Amino-2-methylpropoxy)salicylamide

HRID 1462377Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1462377
[CH3:1][C:2]([N+:16]([O-])=O)([CH3:15])[CH2:3][O:4][C:5]1[CH:13]=[C:9]([C:10]([NH2:12])=[O:11])[C:8]([OH:14])=[CH:7][CH:6]=1>CO>[NH2:16][C:2]([CH3:15])([CH3:1])[CH2:3][O:4][C:5]1[CH:13]=[C:9]([C:10]([NH2:12])=[O:11])[C:8]([OH:14])=[CH:7][CH:6]=1

Komponenten

3

Edukt 1

HCID 137544245-(2-Methyl-2-nitropropoxy)salicylamide

Produkt 1

HCID 137544255-(2-Amino-2-methylpropoxy)salicylamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

11.5 g of 5-(2-methyl-2-nitro-propoxy)-salicylamide in 150 ml of methanol is hydrogenated at 40°-50° and 80 bars, with 5 g Raney Nickel, until the absorption of hydrogen ceases. Filtration and concentration by evaporation of the reaction mixture yield crude 5-(2-amino-2-methyl-propoxy)-salicylamide, which on prolonged standing crystallises from isopropanol, and melts at 115°-117°.

Aufarbeitung

  1. customis hydrogenated at 40°-50°
  2. custom80 bars, with 5 g Raney Nickel, until the absorption of hydrogen ceases
  3. filtrationFiltration and concentration
  4. customby evaporation of the reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-f66121f4e8214b68bc91da5407a5b2c4
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04460580

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