2,3,4,5-Tetrahydro-alpha-methyl-1-benzothiepine-8-methanol → 2,3,4,5-Tetrahydro-1-benzothiepin-8-yl methyl ketone

HRID 1463398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463398
[CH3:1][CH:2]([C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][S:12][C:6]=2[CH:5]=1)[OH:3]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]([C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][S:12][C:6]=2[CH:5]=1)=[O:3]

Komponenten

4

Edukt 1

HCID 199354242,3,4,5-Tetrahydro-alpha-methyl-1-benzothiepine-8-methanol

Produkt 1

HCID 199355372,3,4,5-Tetrahydro-1-benzothiepin-8-yl methyl ketoneAusbeute 94,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

7.80 g of 2,3,4,5-tetrahydro-α-methyl-1-benzothiepine-8-methanol were dissolved in 100 ml of methylene chloride, treated with 50 g of manganese dioxide (MnO2) and the reaction mixture was stirred overnight. Thereafter, the mixture was filtered over a filter aid and the solution was evaporated. There were obtained 7.30 g of 2,3,4,5-tetrahydro-1-benzothiepin-8-yl methyl ketone as a colorless oil.

Aufarbeitung

  1. filtrationThereafter, the mixture was filtered over a filter aid
  2. customthe solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8a7dddd06ea3426dbfb41c4050f52b90
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05300522

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