ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoate → p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

HRID 1463420Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463420
[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1.[OH-].[K+].C(O)C.O>>[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1

Komponenten

3

Edukt 2

HCID 19935413ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoateHCID 23714421Potassium hydroxide ethanol water

Produkt 1

HCID 18990063p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

Versuchsvorschrift

Hydrolysis of the foregoing ester with potassium hydroxide/ethanol/water in analogy to Example 57 gave p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid, melting point 274°-276° C.

Quellen und Nachweise

ORD-Eintrag
ord-c73f2de0cef643c3bd843baea50c28c4
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05300522

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