HCID 19380545, Verbindung → HCID 178513639, Verbindung

HRID 1463741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463741
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1>[Pt].C.O1CCOCC1.C(N(CC)CC)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

Komponenten

4

Edukt 1

HCID 19380545HCID 19380545, Verbindung

Produkt 1

HCID 178513639HCID 178513639, VerbindungAusbeute 45,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 16218561HCID 16218561, VerbindungKatalysatorHCID 68453242Dioxan triethylamineLösungsmittel

Versuchsvorschrift

A mixture of 500 mg of 4-[4-[2-(1,3-dioxolan-2-yl)-ethylidene]cyclohexyl]benzamide and 20 ml of dioxan/triethylamine (vol. 9:1) was hydrogenated by means of 500 mg of 10 percent platinum-charcoal for 2 hours. The reaction mixture was then filtered and the filtrate was evaporated. Recrystallization of the evaporation residue from 40 ml of dioxan gave 230 mg of 4-[trans-4-[2-(1,3-dioxolan-2-yl) ethyl]cyclohexyl]benzamide as colorless crystals.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated
  3. customRecrystallization of the evaporation residue from 40 ml of dioxan

Quellen und Nachweise

ORD-Eintrag
ord-a2afbbc522aa45c18d5482667a6315f6
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302317

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