3,5-Dimethylaniline → 3,5-diMethyl-cyclohexylaMine

HRID 1463835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463835
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[NH2:5]>[Ru]>[CH3:1][CH:2]1[CH2:8][CH:7]([CH3:9])[CH2:6][CH:4]([NH2:5])[CH2:3]1

Komponenten

3

Edukt 1

HCID 79493,5-Dimethylaniline

Produkt 1

HCID 146753743,5-diMethyl-cyclohexylaMine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23950RutheniumKatalysator

Versuchsvorschrift

N-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized as shown in Scheme M. 3,5-Dimethylcyclohexyl amine is synthesized by catalytic hydrogenation of 3,5-dimethyl aniline for 7 to 24 hours. A suitable catalyst is 5% ruthenium on carbon. Hydrogenation pressure may change from 500 to 1500 psi and temperatures may range from 80° to 150°. N-cis cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is formed by reductive amination of cyclpentanone with 3,5-dimethylcyclohexyl amine. The reductive amination may be carried out by hydrogenation using palladium on carbon as catalyst at pressures ranging from 15 to 90 psi. The temperature may range from room temperature to 50°. The reaction time is from 7 to 48 hours.

Aufarbeitung

  1. customN-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized
  2. custommay range from 80° to 150°

Quellen und Nachweise

ORD-Eintrag
ord-5c3fca26dacd4245867dc83c1a5f047a
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302601

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