2-(Thiophen-2-yl)propan-2-amine → N-[1-(2-Thienyl)-1-methylethyl]-3-oxo-4-azaandrost-5-ene-17beta-carboxamide

HRID 1463950

Reaktionsgleichung

Reaktionsgleichung von HRID 1463950
[O:1]=[C:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:21]([OH:23])=O)[NH:3]1.[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[C:29]([NH2:32])([CH3:31])[CH3:30]>>[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[C:29]([NH:32][C:21]([C@H:11]1[CH2:10][CH2:9][C@H:8]2[C@H:7]3[C@H:16]([CH2:15][CH2:14][C@:12]12[CH3:13])[C@:17]1([CH3:20])[C:4]([NH:3][C:2](=[O:1])[CH2:19][CH2:18]1)=[CH:5][CH2:6]3)=[O:23])([CH3:31])[CH3:30]

Komponenten

3

Edukt 2

HCID 450992-(Thiophen-2-yl)propan-2-amineHCID 4754473-Oxo-4-aza-5-androstene-17beta-carboxylic acid

Produkt 1

HCID 67750676N-[1-(2-Thienyl)-1-methylethyl]-3-oxo-4-azaandrost-5-ene-17beta-carboxamideAusbeute 27 %

Versuchsvorschrift

The title compound was prepared in a yield of 27% in a similar manner to that described in Example 2 by reacting 3-oxo-4-azaandrost-5-ene-17β-carboxylic acid and 1-(2-thienyl)-1-methylethylamine.

Quellen und Nachweise

ORD-Eintrag
ord-7a3ba8a056454feeb483c6a283d52c99
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302621

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