4-Morpholinecarbonitrile → HCID 178511978, Verbindung

HRID 1464041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1464041
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:15]([N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)#[N:16]>C1C(O)=CC=CC=1C>[C:4]1([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[NH:2][C:15]([N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)=[NH:16]

Komponenten

4

Edukt 2

HCID 737384-MorpholinecarbonitrileHCID 52843472-Biphenylamine hydrochloride

Produkt 1

HCID 178511978HCID 178511978, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 342M-CresolLösungsmittel

Versuchsvorschrift

A mixture of 2-aminobiphenyl hydrochloride (6.17 g) and 4-cyanomorpholine (5.05 g) in m-cresol (25 ml) was heated at 90°-95° C. for 15 hours to yield N-(2-biphenylyl)-4-morpholine carboxamidine (m.p. 153°-154° C.) which was recrystallised from ethylacetate. N-(2-Biphenylyl)morpholine-4-carboxamidine (3.5 g) was dissolved in methanol (15 ml) and treated with fumaric acid (1.45 g) to give N-(2-biphenylyl)morpholine-4-carboxamidine fumarate (m.p. 222°-223° C.) which was recrystallised from a 1:1 mixture of methanol and ether.

Aufarbeitung

  1. temperaturewas heated at 90°-95° C. for 15 hours

Quellen und Nachweise

ORD-Eintrag
ord-8522274d42924461a68f52fcd6fcfd54
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302720

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