4-Morpholinecarbonitrile → HCID 178488541, Verbindung

HRID 1464042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1464042
Cl.[NH2:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]([N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)#[N:18]>C1C(O)=CC=CC=1C>[CH3:10][O:9][C:7]1[CH:6]=[CH:5][C:4]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:3]([NH:2][C:17]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[NH:18])[CH:8]=1

Komponenten

4

Edukt 2

HCID 737384-MorpholinecarbonitrileHCID 27603625-Methoxy-2-phenylaniline hydrochloride

Produkt 1

HCID 178488541HCID 178488541, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 342M-CresolLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-4-methoxybiphenyl hydrochloride (4.4 g) and 4-cyanomorpholine (3.14 g) in m-cresol (25 ml) was heated at 90°-95° C. for 20 hours to yield N-(4-methoxy-2-biphenylyl)morpholine-4-carboxamidine (m.p. 140°-142° C.) which was recrystallised from ethylacetate. N-(4-Methoxy-2-biphenylyl)morpholine-4-carboxamidine (1.2 g) was dissolved in methanol (10 ml) and treated with fumaric acid (1.45 g) to give N-(4-methoxy-2-biphenylyl)morpholine-4-carboxamidine fumarate [m.p. 120° (dec)] which was recrystallised from a 1:1 mixture of methanol and ether.

Aufarbeitung

  1. temperaturewas heated at 90°-95° C. for 20 hours

Quellen und Nachweise

ORD-Eintrag
ord-bc3b8c65b3594606a3c52d3d7ff73482
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302720

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