Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochloride

HRID 14641

Reaktionsgleichung

Reaktionsgleichung von HRID 14641
C(OC(=O)[NH:7][CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[CH:16][C:17]=2[O:19][CH3:20])[C:12]([C:23](=[O:33])[N:24]([CH3:32])[CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:11][N:10]=1)(C)(C)C.[ClH:35]>CCOC(C)=O>[ClH:35].[CH3:32][N:24]([CH2:25][C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)[C:23]([C:12]1[C:13]2[C:18](=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[CH:14]=2)[C:9]([CH2:8][NH2:7])=[N:10][CH:11]=1)=[O:33]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68614078[6,8-Dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 686147841-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochlorideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

As described in example 1, 88 mg of [6,8-dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 102 mg (>100%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochloride. MS: APCI (M+H) calc'd for C21H24N4O3+H 381.4; found 381.2.

Quellen und Nachweise

ORD-Eintrag
ord-059fc9ff38c549f4a0ffff66bbb9d78d
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732446B1

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