1-Propanol → 2-Propoxythiophene

HRID 1464126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1464126
I[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[Na].[CH2:8]([OH:11])[CH2:9][CH3:10]>>[CH2:8]([O:11][C:2]1[S:3][CH:4]=[CH:5][CH:6]=1)[CH2:9][CH3:10]

Komponenten

4

Edukt 3

HCID 10311-PropanolHCID 189212-IodothiopheneHCID 5360545Sodium

Produkt 1

HCID 190893322-PropoxythiopheneAusbeute 13,5 %

Versuchsvorschrift

Iodothiophene (59 g, 281 mmole) and cupric oxide (11.2 g, 141 mmole) were placed in propanol (420 g) containing sodium (19.7 g, 857 mmole). The mixture was stirred at reflux for 48 hours and then filtered. The filtrate was added to cold water and the water extracted with ethyl ether. The ether layers were combined, dried over magnesium sulfate, filtered, concentrated, and then vacuum distilled from over sodium at 50° C. and 10 torr to provide 5.4 g of product.

Aufarbeitung

  1. temperatureat reflux for 48 hours
  2. filtrationfiltered
  3. additionThe filtrate was added to cold water
  4. extractionthe water extracted with ethyl ether
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. distillationvacuum distilled from over sodium at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-2a2513057be045588a9e1994a95d9d47
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05302724

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