3-Oxobutyronitrile → 2-(2-Chloro-5-pyridylmethylamino)-1-cyano-1-propene

Beteiligte Stoffe

Reaktionsschritte

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

Herkunft & Nachweise