Triethylamine → 2-(2,2-Difluoroethylthio)-phenylsulfonamide

HRID 1464564

Reaktionsgleichung

Reaktionsgleichung von HRID 1464564
C(N(CC)CC)C.[SH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16].Br[CH2:20][CH:21]([F:23])[F:22]>CO>[F:22][CH:21]([F:23])[CH2:20][S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1361862-Bromo-1,1-difluoroethaneHCID 110415322-Sulfanylbenzene-1-sulfonamide

Produkt 1

HCID 109560712-(2,2-Difluoroethylthio)-phenylsulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 145.2 g of the triethylamine salt of 2-mercaptophenylsulfonamide obtained in accordance with Example P6 and 79.7 g of 2-bromo- 1,1 -difluoroethane in 600 ml of methanol is stirred for 16 hours at a temperature of from +55° C. to +60° C. The reaction mixture is then concentrated by evaporation. The residue is stirred with ice-water and the resulting suspension is filtered to yield 120 g (95% of the theoretical yield) of 2-(2,2-difluoroethylthio)-phenyl-sulfonamide having a melting point of from +111° C. to +112° C.

Aufarbeitung

  1. concentrationThe reaction mixture is then concentrated by evaporation
  2. stirringThe residue is stirred with ice-water
  3. filtrationthe resulting suspension is filtered
  4. customto yield 120 g (95% of the

Quellen und Nachweise

ORD-Eintrag
ord-c68afdc046974ede8b33d48f91e70952
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05306693

Verknüpfte Notizen

Wird geladen…