Hydrofluoric Acid → 2-Fluoro-m-xylene

HRID 1464715

Reaktionsgleichung

Reaktionsgleichung von HRID 1464715
Cl[C:2]([O:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:12])=[O:3].[FH:13]>>[CH3:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[C:5]=1[F:13].[F:13][C:2]([O:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:12])=[O:3]

Komponenten

4

Edukt 2

HCID 14917Hydrofluoric AcidHCID 2716182,6-Dimethylphenyl carbonochloridate

Produkt 2

HCID 1230652-Fluoro-m-xyleneHCID 108448272,6-Dimethylphenylfluoroformate

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

500 ml of anhydrous hydrogen fluoride were placed at 0° C. in a stainless steel laboratory autoclave and 1000 g of 2,6-dimethylphenyl chloroformate were added dropwise. The autoclave was then sealed and heated at a maximum temperature of 110° C. for 2 hours, the pressure of the gases formed being released at 30 bar. The reaction mixture was worked up as described in Example 9. Distillation gave 2,6-dimethylfluorobenzene in a yield of 11% and 2,6-dimethylphenyl fluoroformate in a yield of 68%. The latter can be added to a new batch for the preparation of 2,6-dimethylfluorobenzene (see Example 15).

Aufarbeitung

  1. additionwere added dropwise
  2. customThe autoclave was then sealed
  3. customthe pressure of the gases formed
  4. distillationDistillation

Quellen und Nachweise

ORD-Eintrag
ord-f4d44997ea8549468350defcded2853f
Quelldatensatz
uspto-grants-1994_04
Patentnummer
US05306849

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